Health Marker Identification

In common with all of KYomed INNOV’s other activities, our support to clients in identifying health markers and relevant and specific combinations is based on a holistic and personalized approach to health.


Step 1: Collect health data

Health Markers KYomed INNOV Schema KOL

Identifying combinations of health markers requires first of all access to a heterogeneous set of biological, clinical, physiological, behavioral and environmental data from, on the one hand, biological and medical examinations and, on the other, from connected objects and digital medical devices.

Thanks to our wide-ranging activities based on a holistic approach to health, we can undertake all the steps necessary for obtaining raw data:

  • establishing biobanks or cohorts with the associated clinical information;
  • collecting digital data via application tools such as ePRO or the Allergy Diary developed by KYomed INNOV or via the connected objects selected via targeted technological monitoring;
  • collecting biochemical and molecular data (omics) from biological samples and via the network of expertise around KYomed INNOV.

Step 2: Identify key information through a methodologically sound analysis

Once the data of interest is collected, the identification of health markers requires solid skills in health data analysis. This is why KYomed INNOV entrusts each mission of this kind to a project manager experienced in data mining who will gather the necessary resources for managing and analyzing the data.

An excellent understanding of biomathematics, biostatistics and bioinformatics is required in order to integrate the data and undertake the necessary univariate or combinatorial analysis that will identify viable combinations of health markers.

Step 3: Select, with the help of experts, relevant combinations of health markers

The biostatistician works in close collaboration with one or more medical and/or scientific experts to ensure that all relevant metabolic and mechanistic information is taken into account. The final selection of the best combinations will therefore be based on statistical performance criteria, but also on clinical and practical relevance, taking into account feasibility on the ground.

The health markers and candidate combinations will then be validated analytically.

Step 4: Analytical Validation

Once a pertinent health marker or a combination of health markers has been identified, a standard protocol is developed for measuring these markers and performing an analytical validation. This step aims to uncover compelling evidence of the specificity, sensitivity, robustness, detection limits, accuracy, repeatability and reproducibility of the analytical procedure.

At the end of this stage, the health markers and candidate combinations will then be clinically validated (see Clinical Validation of Health Markers).

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